MiRNA-218 Is Frequently Downregulated in Malignant Breast Tumors: A Footprint of Epstein-Barr Virus Infection

Background & Objective: The role of Epstein-Barr Virus in development breast cancer is frequently studied. In this regard, miRNAs are among the contributing elements molecular pathophysiology EBV-related diseases. addition, a growing number host believed to be implicated pathogenesis cancer. MiR-218 tumor suppressive miRNA that subjected dysregulation various EBV-associated cancers. We aimed investigate frequency EBV and its relationship with expression status miR-218 adjacent normal tissue.Methods: A total 51 fresh malignant tissues (cases) their (controls) were collected. Nested-PCR RT-qPCR set identify cases controls, respectively.Results: Out all samples, 6.8% (7/102) comprising 11.6% (6/51) 1.9% (1/51) control positive for (P<0.05). Quantitative data showed was significantly downregulated compared (P<0.0001). reduced associated adverse clinical outcomes, metastasis, higher grades malignancy. Given presence EBV, lower observed group comparison Conclusion: Our results raise possibility relation between infection downregulation propose further investigations regard.